Finasteride-Loaded Phospholipid-Bile Salt Mixed Micelles for Targeted Follicular Delivery in Androgenetic Alopecia

The study explores a novel topical delivery system for Finasteride (FNS) using phospholipid-bile salt mixed micelles to target hair follicles in androgenetic alopecia (AGA) while minimizing systemic absorption. The micelles, composed of egg phosphatidylcholine and sodium cholate, demonstrated high encapsulation efficiency (98.5%) and sustained drug release over 48 hours. In an AGA mouse model, these micelles significantly improved hair regrowth, increased follicle number and length, and enhanced follicular proliferation compared to a traditional FNS solution. Importantly, the micelle-treated group maintained higher serum dihydrotestosterone levels, indicating reduced systemic exposure. These results suggest that EPC-SC micelles offer a promising and safer alternative for AGA treatment.