Hair Growth-Promoting Activity of Flavone-Rich Fractions Derived from Eremochloa Ophiuroides Extracts

This study examined the hair growth-promoting effects of flavone-rich fractions from Eremochloa ophiuroides extracts in a C57BL/6 mouse model. Mice were treated topically for 21 days with distilled water, 3% minoxidil, or E. ophiuroides fractions. The E. ophiuroides-treated groups showed significant hair regrowth, comparable to minoxidil. Molecular analysis revealed increased alkaline phosphatase activity, reduced transforming growth factor-β expression, and elevated vascular endothelial growth factor expression, indicating enhanced anagen induction and improved follicular microenvironment. Histological and electron microscopy analyses confirmed increased dermal thickness, follicular development, hair density, and shaft diameter. These results suggest that E. ophiuroides-derived fractions could be effective natural agents for promoting hair growth.