Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

The document reviews the potential of flavonoids as wound-healing agents, emphasizing their anti-inflammatory, antioxidant, and pro-collagen properties. Flavonoids, found in fruits and vegetables, can influence wound healing through various pathways, such as Wnt/β-catenin, TGF-β, and NF-κB, which are crucial for tissue remodeling and inflammation regulation. Clinical trials have shown promising results, with quercetin improving wound healing in diabetes patients and a combination of flavonoids accelerating venous leg ulcer healing. Despite these findings, further research is needed to fully understand their mechanisms and optimize their therapeutic use, especially in integrating advanced technologies like nanotechnology. The review highlights the need for natural-product-based treatments due to the limitations of conventional drugs and the growing global chronic wound care market.