FOXP3+ Regulatory T Cells And Age-Related Diseases

Regulatory T (Treg) cells played a crucial role in maintaining immune homeostasis, and their dysfunction was linked to age-related diseases, including cancers and autoimmune diseases. The phenomenon of 'inflammaging' was characterized by increased inflammatory markers in the blood of aged individuals. Evidence suggested that targeting Treg cells could be a promising therapeutic approach for these conditions. Drugs aimed at Treg cells showed promising results, enhancing CD8⁺ T-cell-mediated cytotoxicity against tumors and infected cells. The review highlighted the need for a deeper understanding of Treg cell function to develop new immune therapies for aging and discussed the challenges of translating these therapies into clinical practice.