Synergistic Sequential Emission of Fractional 10.600 and 1540 nm Lasers for Skin Resurfacing: An Ex Vivo Histological Evaluation

The study evaluated the synergistic effects of using fractional 10.600 nm CO2 and 1540 nm lasers for skin resurfacing on ex vivo sheep skin. The combination of these wavelengths enhanced skin remodeling benefits, such as collagen production and tissue shrinkage, more effectively than using each laser alone. The 10.600–1540 nm sequence resulted in a significant area reduction of 11.96%, compared to 6.8% with CO2 alone. The synergy increased the coagulation volume and thermal lesion coverage without affecting tissue healing, suggesting improved skin tightening and regeneration with reduced downtime and side effects. The study also highlighted the potential for combining laser treatments with other modalities for better results.