From the Cochrane Library: Interventions for Nail Psoriasis

Nail psoriasis affects 80-90% of psoriasis patients, but research is limited due to poor trial quality and outdated reviews. The 2013 Cochrane review of 18 trials with 1,266 patients found inconclusive evidence for topical therapies, while systemic therapies like infliximab and golimumab showed significant improvements but had high adverse event rates. The slow growth of nails compared to skin complicates research, requiring longer trials. Current guidelines suggest starting with topical and intralesional treatments, reserving systemic options for severe cases. There is a need for updated trials and improved research standards focusing on nail outcomes.