A GelMA Hydrogel Co-Loaded With Resveratrol, 18-β-Glycyrrhetinic Acid, And Berberine For The Combination Therapy Of Infected Wounds

The study developed a gelatin methacrylate hydrogel dressing co-loaded with resveratrol, 18-β-glycyrrhetinic acid, and berberine to treat infected wounds, leveraging their anti-inflammatory, antibacterial, and antioxidant properties. In a mouse model with full-thickness dorsal skin defects, the co-loaded dressing achieved a 77.92% wound closure rate by Day 12, demonstrating superior infection clearance, continuous epidermis formation, and increased hair follicle regeneration compared to dressings with single components. The findings suggest that this combination therapy significantly enhances wound healing and skin structure regeneration.