Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia

May 2024 in “ JAMA Dermatology ”

Tuntas Rayinda, Sheila M. McSweeney, Evangelos Christou, Chuin Ying Ung, David A. Fenton, John A. McGrath, Nick Dand, Michael A. Simpson, Christos Tziotzios

frontal fibrosing alopecia FFA CYP1B1 oral contraception HLA-B*07:02 ST3GAL1 SEMA4B hormone metabolism p.Asn453Ser immune response birth control pills

TLDR Oral contraceptive use may increase the risk of frontal fibrosing alopecia in women with a specific CYP1B1 gene variant.

This study examined the interaction between the CYP1B1 gene variant (c.1358A>G, p.Asn453Ser) and oral contraceptive pill (OCP) use on the risk of frontal fibrosing alopecia (FFA) in 489 female patients and 34,254 controls. It found that the presence of an asparagine residue at position 453 of CYP1B1 was associated with a 1.9 times greater risk of FFA in OCP users, but no effect was observed in non-users. This suggests that OCP use may increase FFA risk in carriers of the CYP1B1 risk allele, emphasizing the role of gene-environment interactions in FFA pathogenesis.

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research Frontal Fibrosing Alopecia: An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

8 citations , July 2020 in “Clinical, cosmetic and investigational dermatology”

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.

research Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

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