Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

August 2020 in “ Genes ”

Dominique J Wiener, Kátia R. Groch, Magdalena A. T. Brunner, Tosso Leeb, Vidhya Jagannathan, Monika Welle

anagen telogen hair follicles interfollicular epidermis gene expression BMP2 BMP4 BMP7 KRT17 KRT25 differentially expressed genes molecular mechanisms hair growth hair loss growth phase resting phase skin

TLDR Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

The study "Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis" analyzed gene expression in different stages of hair follicle development and interfollicular epidermis (IFE) in dogs. Researchers identified distinct gene expression patterns associated with the anagen (growth) and telogen (resting) phases, highlighting genes like BMP2, BMP4, and BMP7 in anagen, and KRT17 and KRT25 in telogen. The study found 1,236 differentially expressed genes, with 858 upregulated in anagen and 378 in telogen. This research provided insights into the molecular mechanisms of hair growth and loss, suggesting dogs as a better model for human skin diseases compared to mice.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

38 / 38 results

research Genetic Hair Disorders: A Review

26 citations , July 2019 in “Dermatology and Therapy”

The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.

research Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

49 citations , July 2019 in “British Journal of Dermatology”

Wnt signaling is important for the change from the resting phase to the growth phase in human hair cycles.

A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions

research A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions

10 citations , March 2019 in “Human Genetics”

A genetic mutation in the SGK3 gene causes hairlessness in Scottish Deerhounds and may relate to human hair loss.

research Bald Thigh Syndrome in Sighthounds: Revisiting the Cause of a Well-Known Disease

5 citations , February 2019 in “PloS one”

Bald thigh syndrome in sighthounds is caused by structural defects in hair shafts due to downregulated genes and proteins.

research NIPAL4 Deletion Identified in an American Bully with Autosomal Recessive Congenital Ichthyosis and Response to Topical Therapy

7 citations , February 2019 in “Veterinary medicine and science”

An American Bully with a genetic skin condition improved significantly with specific topical treatments.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations , October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations , October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research In Vitro Identification of a Stem Cell Population from Canine Hair Follicle Bulge Region

5 citations , December 2017 in “Tissue and cell/Tissue & cell”

Researchers found stem cells in dog hair follicles using specific markers.

research Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X

18 citations , October 2017 in “PLOS ONE”

The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.

research Distinct Expression Profile of Stem Cell Markers, LGR5 and LGR6, in Basaloid Skin Tumors

9 citations , January 2017 in “Virchows Archiv”

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

research Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

research Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

245 citations , October 2015 in “Nature medicine”

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

research To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

research Stem Cell Dynamics in the Hair Follicle Niche

135 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives

79 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata may be treated by restoring hair follicle immune privilege and adjusting immune responses.

research Wnt Signaling in Skin Development, Homeostasis, and Disease

260 citations , December 2012 in “Cold Spring Harbor Perspectives in Biology”

Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations , June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs

research Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs

28 citations , February 2012 in “PLoS ONE”

A PKP1 gene mutation causes skin fragility and hair loss in Chesapeake Bay retriever puppies.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations , April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.

research Characterization of BMP2 Gene Expression in Embryonic and Adult Inner Mongolia Cashmere Goat (Capra Hircus) Hair Follicles

18 citations , December 2009 in “Canadian Journal of Animal Science”

The BMP2 gene is more active in the early growth phase of Cashmere goat hair and may affect hair regeneration and textile production.

research Canine Hair-Follicle Keratinocytes Enriched With Bulge Cells Have the Highly Proliferative Characteristic of Stem Cells

37 citations , October 2009 in “Veterinary Dermatology”

Canine hair follicles contain stem-like cells with high growth potential.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

127 citations , December 2007 in “Journal of Investigative Dermatology”

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Learning From Nudity: Lessons From The Nude Phenotype

86 citations , October 2005 in “Experimental Dermatology”

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

60 citations , December 2003 in “Journal of Investigative Dermatology”

K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.

research Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research Keratin 17 Gene Expression During the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

Related Research

1 / 1 results

research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation

April 2017 in “Journal of Dermatological Science”

Certain flavonoids can improve the growth of pigmented hair in mice.