Gene Expression of FOXA1 and CCL2 in Different Phenotypes of Infertile Women with Polycystic Ovarian Syndrome

This study examined the gene expression of FOXA1 and CCL2 in 60 infertile women with different phenotypes of polycystic ovarian syndrome (PCOS) compared to 50 healthy controls. Results showed that FOXA1 expression was significantly higher in all PCOS phenotypes, especially in phenotype B. CCL2 expression was also elevated in all PCOS phenotypes, with the highest levels in phenotype C, followed by phenotype B, while phenotypes A and D showed no significant difference. These findings suggest phenotype-specific gene expression alterations in PCOS, offering insights that could lead to personalized treatment approaches to enhance reproductive outcomes for affected women.