Gene Expression of FOXA1 and CCL2 in Different Phenotypes of Infertile Women with Polycystic Ovarian Syndrome

This study analyzed the gene expression of FOXA1 and CCL2 in 60 infertile women with PCOS, divided into four phenotypes, compared to 50 healthy controls. It found that FOXA1 expression was significantly higher in all PCOS phenotypes, especially in phenotype B, while CCL2 expression was notably elevated in phenotypes C and B. These results suggest phenotype-specific genetic alterations in PCOS, indicating the potential for personalized treatment approaches. However, the small sample size limits the generalizability of the findings, and larger studies are needed for validation.