Gene Variants Associated With Acne Vulgaris Presentation and Severity: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis investigated genetic factors associated with acne vulgaris presentation and severity, analyzing data from 982 acne cases and 846 controls. The study identified 60 genes and 100 variants linked to acne, focusing on genes related to inflammatory responses and sebaceous gland function. Notably, the TNF rs1800629 A allele and CYP17A1 rs743572 T allele were associated with reduced risks of mild and severe acne, respectively, while the FST rs629725 A allele was linked to a modestly increased risk. The study also identified 15 novel SNPs in the TLR4 gene associated with acne. These findings highlighted the potential of genetic variants in influencing acne risk and underscored the importance of understanding genetic susceptibility to develop effective treatments. However, significant heterogeneity and publication bias were noted, emphasizing the need for further research.