Generation of functionally active resident macrophages from adipose tissue by 3D cultures

    June 2024 in “ Frontiers in Immunology ”
    Adèle Arlat, Marie-Laure Renoud, Jean Nakhle, Miguel Thomas, Jessica Fontaine, Emmanuelle Arnaud, Cédric Dray, Hélène Authier, Paul Monsarrat, Agnès Coste, Louis Casteilla, Marielle Ousset, Béatrice Cousin
    TLDR 3D cultures can create active macrophages from fat tissue.
    The study presents a 3D in-vitro system for generating and culturing functional adipose tissue (AT)-resident macrophages without requiring cell sorting. This innovative system provides a valuable tool for investigating the differentiation and function of AT-macrophages in various physiological and pathological settings.
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