Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in Mouse Plasma

    March 2024 in “ Preprints.org ”
    Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Meth Jayatilake, Vijayalakshmi Sridharan, José A. Fernández, John H. Griffin, Hartmut Weiler, Marjan Boerma, Amrita K. Cheema
    TLDR Activated protein C helps protect mice from radiation damage.
    The study examines the impact of genetic upregulation of activated protein C (APC) on mitigating delayed metabolic effects of acute radiation exposure in mice. Involving 67 mice, the research found that transgenic APCHi mice with elevated APC levels exhibited fewer radiation-induced metabolic disruptions compared to wild-type mice, suggesting a protective effect of APC against radiation-induced metabolic dysregulation. The study also observed gender-specific metabolic changes, highlighting the potential of APC as a therapeutic target for reducing late radiation effects and emphasizing the need for further research on APC's role in radiation injury mitigation.
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