Genetics of Infertility and Assisted Fertilization in the Bible: The Case of Abraham and His Family
August 2025
in “
Andrology
”
Research cited in this study
4 / 4 resultsresearch The Search for the Causes of Common Hyperandrogenism, 1965 to Circa 2015
From 1965 to 2015, significant progress was made in understanding androgen excess disorders like premature adrenarche and polycystic ovary syndrome (PCOS). Key discoveries include the identification of unique plasma androgen patterns and the role of 11-oxytestosterones as major adrenal androgens. Research into PCOS pathogenesis highlighted areas such as neuroendocrinology, insulin resistance, and genetics, with genome-wide studies revealing the steroidogenic regulator DENND1A as a key factor. The DENND1A.V2 splice variant is overexpressed in PCOS theca cells, contributing to the PCOS phenotype. Obesity worsens PCOS symptoms through insulin resistance and increased testosterone production. Despite these advances, much remains to be understood about these disorders.
research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria
The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.
research Is Polycystic Ovary Syndrome a Sexual Conflict? A Review
The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
research The Polycystic Ovary Syndrome Evolutionary Paradox: A Genome-Wide Association Studies-Based, In Silico, Evolutionary Explanation
The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.