TLDR CDKN2AIP gene is less active in nevus sebaceous, affecting related RNA networks.
The study examined the differential expression of mRNAs and lncRNAs in nevus sebaceous (NS) compared to normal scalp tissues using RNA-seq analysis, involving 4 subjects. It identified 90 mRNAs and 17 lncRNAs with significant differential expression, highlighting the low expression of the CDKN2AIP gene in NS. This gene is linked to the p53-HDM2-p21 and Wnt/β-catenin pathways, important for cell proliferation and hair follicle development. A ceRNA network was constructed to explore CDKN2AIP interactions, suggesting its role in NS pathogenesis. The study's limitations included a small sample size and reliance on predictive software, necessitating further research to validate these findings and understand the molecular mechanisms.
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