Genome-Wide Differential Expression Profiles in Nevus Sebaceous Revealed Low Expression of CDKN2AIP and Construction of a ceRNA Network

The study examined the differential expression of mRNAs and lncRNAs in nevus sebaceous (NS) compared to normal scalp tissues using RNA-seq analysis, involving 4 subjects. It identified 90 mRNAs and 17 lncRNAs with significant differential expression, highlighting the low expression of the CDKN2AIP gene in NS. This gene is linked to the p53-HDM2-p21 and Wnt/β-catenin pathways, important for cell proliferation and hair follicle development. A ceRNA network was constructed to explore CDKN2AIP interactions, suggesting its role in NS pathogenesis. The study's limitations included a small sample size and reliance on predictive software, necessitating further research to validate these findings and understand the molecular mechanisms.