The Riddle of Genuine Skin Microrelief and Wrinkles

The document explored the ageing process of human skin, focusing on the formation of wrinkles due to both intrinsic factors like genetic programming and extrinsic factors such as UV exposure. It described changes in skin microrelief with age, leading to anisotropic patterns and dermal atrophy. Wrinkles were categorized into four types: atrophic crinkles, elastotic creases, dynamic expression lines, and gravitational folds, each with distinct causes and characteristics. The study highlighted the complexity of wrinkle formation, emphasizing the need to identify the primary cause for effective treatment design, as wrinkles resulted from a combination of mechanisms rather than a single process.