Geographic Variation And Host Genetics Shape The Human Skin Microbiome

This study investigates the influence of host genetics and geography on the human skin microbiome by analyzing 1,756 samples from 327 individuals across five countries. The research reveals that geography has a greater impact on microbiome variation than skin type, while host genetics introduces unique structures, particularly in Chinese individuals. A genome-wide association analysis identifies 107 SNPs linked to 22 microbial taxa, suggesting roles for host genes in skin structure, immunity, and lipid metabolism. The study also notes geographic divergence and co-adaptation between Cutibacterium acnes and its phages. Additionally, host-infecting viruses, such as papillomaviruses, are linked to increased microbial diversity and immune-modulatory functions. These findings underscore the importance of host genetics in shaping skin microbiome ecology and the benefits of geographically diverse analyses.