Evaluation of Glutathione-Related Antioxidant Enzyme Activity in Patients with Polycystic Ovary Syndrome and Investigation of Clinical Correlations

    December 2024 in “ The Eurasia Proceedings of Science Technology Engineering and Mathematics ”
    Ali Hameed Mahmood AL - QAYSI, Şevki Adem, Omeed Akbar Ali
    TLDR Higher ꝩ-GCS enzyme levels in PCOS patients may play a role in the disease.
    This study investigated the role of glutathione-related enzymes in patients with Polycystic Ovary Syndrome (PCOS) by comparing 40 PCOS patients with 40 healthy controls. The research focused on the levels of gamma-glutamyl transferase (GGT) and gamma-glutamyl cysteine synthetase (ꝩ-GCS) using the ELISA technique. While no significant difference in GGT levels was found between the two groups, ꝩ-GCS levels were significantly higher in the PCOS group (P<0.05). This suggests that glutathione metabolism, particularly the activity of ꝩ-GCS, plays a crucial role in the progression of PCOS, potentially due to its involvement in glutathione catalysis. The findings highlight the importance of glutathione in influencing the mechanisms of PCOS, a condition that significantly impacts women's health.
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