Glypican-1, -4, and -6 Participate in Hair Follicle Stem Cell Differentiation via Specific Interactions with BMP2R, Fz7, and Patched 1
October 2024
in “
SPIRE - Sciences Po Institutional REpository
”
glypican-1 glypican-4 glypican-6 BMP2R Fz7 Patched 1 hair follicle stem cell HFSC human hair follicle dermal papilla cells HHFDPC keratinocytes of the outer root sheath KORS human dermal microvascular endothelial cells HDMEC heparan sulfate-type glycosaminoglycan heparan sulfate proteoglycans androgenic alopecia keratinocytes outer root sheath heparan sulfate
TLDR Glypicans help hair follicle stem cells differentiate by interacting with specific receptors, influencing hair growth.
The study examines the role of glypicans (GPC1, GPC4, and GPC6) in hair follicle stem cell (HFSC) differentiation, focusing on their interactions with BMP2R, Fz7, and Patched 1 receptors. It highlights the involvement of human hair follicle dermal papilla cells (HHFDPC), keratinocytes of the outer root sheath (KORS), and human dermal microvascular endothelial cells (HDMEC) in regulating HFSC fate. HHFDPCs promote differentiation into secondary hair germ progenitors, while KORS and HDMECs induce differentiation into outer root sheath progenitors. The study also notes the impact of heparan sulfate-type glycosaminoglycan chains on HFSC differentiation, suggesting potential pathways for developing treatments for androgenic alopecia by targeting heparan sulfate proteoglycans. The findings emphasize the complex interplay of signaling pathways in HFSC differentiation, with potential implications for understanding hair growth and regeneration.
