Graham-Little Syndrome — a rare entity of both scarring and non-scarring alopecia concomitance

    January 2019 in “ Via Medica Journals
    Magdalena Radziszewska, Adriana Rakowska, Lidia Rudnicka, Joanna Czuwara
    TLDR Graham-Little syndrome causes hair loss and skin bumps, with difficult treatment options.
    Graham-Little syndrome was a rare condition characterized by a triad of symptoms: multifocal progressive cicatricial alopecia on the scalp, non-scarring hair loss in the axillae and pubic areas, and keratosis pilaris-like eruptions on the trunk and extremities. The etiology of the syndrome was unknown, and diagnosis relied on clinical presentation, trichoscopic findings, and histopathological analysis. Treatment was challenging and included topical or systemic corticosteroids, retinoids, and PUVA therapy, with varying degrees of efficacy. The document presented a case of this syndrome and discussed practical aspects of diagnosis and treatment.
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