Serum Granulysin Levels in Vitiligo and Alopecia Areata: A Potential Biomarker for Disease Activity and Dermoscopic Evaluation

This study investigated serum granulysin (GNLY) levels in 65 patients with vitiligo and alopecia areata (AA) compared to 15 healthy controls. Results showed that both vitiligo and AA patients had significantly higher GNLY levels than controls, with the highest levels in the active vitiligo group. While GNLY levels did not correlate with age, sex, or certain clinical features, they were significantly associated with the Vitiligo Disease Activity score and specific dermoscopic signs of activity. These findings suggest that elevated GNLY levels may play a pathogenic role and serve as a potential biomarker for monitoring disease activity in vitiligo and AA.