Stability And Efficacy Of Green Solvent And Natural Excipient-Based Semisolid Formulations Compared With Conventional Formulations: A Review

This review analyzed 36 studies to compare the stability and efficacy of green solvent- and natural excipient-based semisolid formulations with conventional ones. Out of 20 studies on efficacy, 11 favored green formulations, 7 found them equivalent, and 2 had mixed results. Safety profiles were generally comparable or better for green formulations, with no serious adverse events reported. However, stability data were limited, with only 9 studies addressing stability parameters and lacking long-term data. While green formulations show promising efficacy and safety, their stability compared to conventional formulations remains unproven, limiting their readiness for widespread use.