Ha 1 and Ha 4 Trichocytic Cytokeratin Subunits Expression During Hair Development in Rat Embryonal Skin

    January 1993 in “ Nihon Chikusan Gakkaiho ”
    Katsuhiko ARAI, Ayako Matsunaga, Kohkichi UEHARA
    TLDR Trichocytic cytokeratin expression starts earlier in whiskers than in body hair during rat embryo development.
    The study investigated the expression of trichocytic cytokeratin subunits during hair development in rat embryonal skin, focusing on the Ha 1 and Ha 4 subunits. Researchers developed a monoclonal antibody (MAb 17) that specifically reacted with trichocytic cytokeratins, particularly Ha 1 and Ha 4, but not with other type I or type II keratin families. Using two-dimensional gel electrophoresis and immunoblotting, they found that MAb 17 recognized epitopes preserved in Ha 1 and Ha 4. Immunohistochemical analysis revealed that trichocytic cytokeratin expression began at embryonic day 18 in body hair and by day 17 in whiskers, suggesting a correlation between hair follicle formation and the onset of trichocytic cytokeratin expression, with whisker follicle formation occurring earlier than body hair.
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