Haemostatic and Biocompatibility Evaluation of Alginate-Functionalized Polylactide Composite Containing Zinc Sulphide and Hardystonite

    August 2025 in “ Marine Drugs ”
    Anna Kaczmarek, Zdzisława Mrozińska, Jerzy J. Chruściel, Michał Juszczak, Katarzyna Woźniak, Marcin H. Kudzin
    TLDR The new composite material is safe and has anticoagulant properties.
    The study evaluated a new composite material, PLA-ALG-ZnS-HT, for haemostatic potential and biocompatibility in blood-contacting applications. The composite, made by modifying polylactide (PLA) with sodium alginate (ALG), hardystonite (HT), and zinc sulphide (ZnS), showed a uniform coating and increased surface area and pore volume. Haemostatic testing indicated prolonged activated partial thromboplastin time (aPTT) due to Zn<sup>2+</sup> interactions, suggesting anticoagulant properties. Biocompatibility tests demonstrated high cell viability and no genotoxic effects, indicating the material is safe for blood and skin cells.
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