Author Response: Hair Follicle Dermal Condensation Forms via FGF20 Primed Cell Cycle Exit, Cell Motility, and Aggregation

The study investigated the role of Fgf20 in hair follicle dermal condensation, focusing on cell cycle exit, cell motility, and aggregation. It found that mesenchymal cell condensates formed through directional migration, with Fgf20 playing a crucial role in priming these processes. However, the exact timing and sequence of events remained unresolved. The research faced challenges in distinguishing cell markers and validating cell cycle exit, and while Fgf20 was necessary for p21 expression, it was insufficient alone to induce cell cycle exit, indicating the involvement of additional factors. The study provided insights into hair follicle development but highlighted the need for further investigation and more sophisticated tools.