Hair Growth-Promoting Potential of Semecarpus Anacardium: Mechanistic Insights and Pharmacological Evidence

The review discusses the potential of Semecarpus anacardium, an Ayurvedic plant, in promoting hair growth due to its bioactive compounds like anacardic acid, biflavonoids, and phenolic compounds. These compounds have antioxidant, anti-inflammatory, and antimicrobial properties that protect hair follicles and enhance follicular cycling. The plant influences key signaling pathways important for follicle regeneration. However, raw preparations can be toxic, highlighting the need for detoxification and safe formulation. Current evidence is mainly from in vitro and animal studies, with limited human trials, indicating a need for further research on extraction methods, delivery systems, and clinical evaluations to confirm its efficacy and safety in humans.