Hair Number per Follicular Unit as a Marker of Treatment Response to Combined Autologous Scalp‐Derived Micrografts and Allogeneic <scp>SHED</scp> ‐ <scp>CM</scp> in Male Androgenetic Alopecia

    Tomoko Kamishima, Ai Minamimura, Chie Hirabe, Junichi Taguchi
    TLDR The treatment improved hair growth and was safe, with hair number per follicle indicating success.
    The study evaluated the efficacy and safety of a combined treatment using autologous scalp-derived micrografts (MG) and allogeneic dental pulp stem cell-derived conditioned medium (SHED-CM) in 59 patients with male androgenetic alopecia (MAGA). The treatment achieved a 69.5% response rate without serious adverse events, though 33.9% of patients experienced mild, self-limited injection-site pain and petechiae. Responders showed increases in hair diameter and hair number per follicular unit (HN/FU), which was a key marker distinguishing them from non-responders. The study concluded that the combined treatment was well-tolerated and led to significant improvements, with changes in HN/FU serving as a practical marker for assessing treatment response.
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