Enhancing Hair Regrowth in Pediatric Morphea En Coup De Sabre by Fractional CO2 Laser-Assisted Exosome Delivery

This case study explores the use of fractional CO2 laser-assisted exosome delivery for hair regrowth in a 6-year-old girl with Morphea en coup de sabre, a condition leading to scarring alopecia. Traditional treatments, including topical steroids and systemic methotrexate, showed minimal success. The novel intervention involved applying rose stem cell-derived exosomes post-laser treatment, resulting in visible hair regrowth by week six and further improvement by week ten. While promising, the study is limited by its single-subject design and lack of inter-observer validation. The findings suggest potential for exosome therapy in treating refractory skin conditions, though larger studies are needed to confirm efficacy and safety.