Haplotypes Spanning Centromeric Regions Reveal Persistence of Large Blocks of Archaic DNA

    June 2018 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Sasha A. Langley, Karen H. Miga, Gary H. Karpen, Charles H. Langley
    TLDR Humans have ancient DNA from Neanderthals and other lineages in their chromosomes, affecting traits and evolution.
    The study revealed that centromere-proximal regions of human chromosomes, known as cenhaps, exhibited significant genetic diversity, including entire Neanderthal centromeres and ancient lineages among Africans. These haplotypes contained variations, such as differences in α-satellite DNA content, which could affect chromosome transmission. The findings provided new opportunities to explore the role of these regions in phenotypic variation and the evolution of genomic regions, particularly in meiosis and mitosis.
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