The Healing Process Without Scarring – Literature Review

September 2019 in “ Romanian Journal of Pediatrics ”

Ancuţa Muntean, Ionica Stoica, Dan Mircea Enescu

fetal skin healing regenerative healing fibrotic tissue postnatal wound healing cellular mechanisms molecular mechanisms

TLDR Fetal skin can heal without scars, offering insights for better wound treatments.

The document reviewed the unique characteristics of fetal skin healing, which had the ability to regenerate without forming scars, unlike typical postnatal wound healing that results in scar tissue and potential disabilities. Understanding the cellular and molecular mechanisms of this fetal phenotype was crucial, as it could lead to new therapeutic targets aimed at reducing fibrotic tissue formation in postnatal wound healing. The article aimed to present these regenerative healing features concisely, highlighting their potential to facilitate scarless healing.

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Research cited in this study

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research Scarless Wound Healing: Finding the Right Cells and Signals

132 citations , June 2016 in “Cell and Tissue Research”

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

research Improved Cutaneous Wound Healing After Intraperitoneal Injection of Alpha-Melanocyte-Stimulating Hormone

29 citations , November 2014 in “Experimental Dermatology”

Injecting alpha-melanocyte-stimulating hormone in mice improved skin healing and reduced scarring.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research Mammalian Fetal Organ Regeneration

32 citations , January 2005 in “Advances in Biochemical Engineering / Biotechnology”

Fetal wounds heal without scarring because of different biological factors, which could help improve adult wound healing.

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