In Vitro Cultured Human-Derived HFMSCs Show Potential to Promote Wound Healing

January 2026 in “ China National GeneBank DataBase ”

章栋林(ZhangDonglin)

hair follicle-derived mesenchymal stem cells HFMSCs wound healing extracellular matrix remodeling progenitor cell markers single-cell RNA sequencing mesenchymal stem cells murine skin defect model

TLDR Human hair follicle stem cells can help heal wounds faster.

The study investigates the potential of human hair follicle-derived mesenchymal stem cells (HFMSCs) in promoting wound healing. An in vitro culture system was established for HFMSCs, confirming their mesenchymal identity. Comparative transcriptomic analysis using single-cell RNA sequencing revealed that HFMSCs have distinct molecular signatures compared to umbilical cord-derived MSCs (UCMSCs), with HFMSCs showing enrichment in extracellular matrix remodeling pathways and progenitor cell markers. Functionally, HFMSCs demonstrated superior migratory capacity and accelerated wound closure in a murine skin defect model, highlighting their therapeutic potential for advanced wound healing therapies.

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