14 citations
,
May 2022 in “Stem cell reports” The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
July 2024 in “Journal of Investigative Dermatology” This study presents a novel multicellular skin organoid (SO) system that effectively models human skin's complexity, including its microanatomy, functionality, and pathological responses. By culturing a mixture of six key skin cell types for 21 days, the SOs maintained a skin-like layered microstructure and demonstrated functions such as epidermal barrier integrity and melanogenesis. The system was tested for skin physiology using retinol metabolism and barrier integrity with 4kDa Dextran-FITC diffusion. It successfully modeled skin injury through chemical and UVB exposure, showing reactions consistent with known irritation indices and stress responses. Additionally, melanoma cells within the SOs mimicked cancer spread and invasion, providing a reliable platform for studying skin physiology, damage, and cancer in dermatopathology.
31 citations
,
January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
January 2026 in “Wound Repair and Regeneration” Skin organoids are improving research but need better blood supply, nerve function, and immune system integration.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists improved how to make skin-like structures from stem cells using special gels and a device that controls growth signals, leading to better hair and skin features.
