Histocompatibility of Improved Follicular Unit-Like Wigs for Hair Transplantation

The study aimed to improve follicular unit-like wigs for transplantation and assess their histocompatibility. Medical-grade polycaprolactone was used to create the wigs, which were implanted into the scalps of New Zealand white rabbits. Histological analysis showed that the improved wigs had a milder inflammatory response one week post-surgery, with fewer inflammatory cells (122.67 ±4.55) compared to the original wigs (143.33±16.42), with a significant difference (P<0.05). Over time, inflammatory cells decreased, and fibroblasts and collagen fibers increased, indicating good tissue compatibility for both wig types. By one month and six months post-surgery, the difference in inflammatory cell count between the two groups was not statistically significant. The improved wigs demonstrated good histocompatibility, providing a solid foundation for long-term transplantation research.