Hormonal Profile and Anthropometric Indices As Determinants of Metabolic Risk in Polycystic Ovary Syndrome: A Prospective Observational Study

March 2026 in “ Cureus ”

Nigil Napolean, Shraddha Chaurasiya, Soumya Khanna, Shikha Sachan, Royana Singh, Jhumur Dey

TLDR Women with PCOS have hormonal imbalances and increased central obesity, highlighting the need for early detection and management.

This study on polycystic ovary syndrome (PCOS) found that women with PCOS have significant hormonal imbalances, including elevated levels of LH, FSH, and AMH, and increased central obesity as indicated by higher BMI, WHR, and WHtR. The study also noted a lower 2D:4D digit ratio in women with PCOS, suggesting a link to prenatal androgen exposure. Despite these differences, fasting glucose and lipid profiles were similar between PCOS patients and healthy controls. The findings emphasize the need for early detection and comprehensive management of PCOS due to its complex interplay of developmental, metabolic, and endocrine factors.

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research Polycystic Ovary Syndrome and Reproductive Health: A Comprehensive Review

9 citations , December 2024 in “Clinical and Experimental Obstetrics & Gynecology”

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research Androgen Excess: A Hallmark of Polycystic Ovary Syndrome

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research Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome

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Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

research Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

32 citations , June 2019 in “Frontiers in Endocrinology”

Polycystic Ovary Syndrome (PCOS) is common in women with conditions like anovulation, hirsutism, hair loss, and type 2 diabetes, and it can lead to health risks like heart disease, obesity, insulin resistance, and depression. Non-Classic Congenital Adrenal Hyperplasia (NC-CAH) is also discussed.

research Polycystic Ovary Syndrome Patients with High BMI Tend to Have Functional Disorders of Androgen Excess: A Prospective Study

23 citations , January 2016 in “Journal of Nanjing Medical University”

Overweight women with PCOS are more likely to have excess male hormones.