Human Hair Follicle Dermal Papilla Cell, Dermal Sheath Cell, and Interstitial Dermal Fibroblast Characteristics

September 1996 in “ PubMed ”

Hsien‐Ching Chiu, Chung‐Hsing Chang, Jau‐Shiuh Chen, Shiou‐Hwa Jee

hair follicle dermal papilla cells dermal sheath cells interstitial dermal fibroblasts smooth muscle alpha-actin glycosaminoglycans TGF-beta 2 IL-6 IGF-I transforming growth factor beta 2 interleukin 6 insulin-like growth factor I

TLDR DP and DS cells are different from DF cells in structure and function.

The study compared the characteristics of cultured human hair follicle dermal papilla (DP) cells, dermal sheath (DS) cells, and interstitial dermal fibroblasts (DF cells) from scalp tissue. DP and DS cells exhibited aggregative behavior and expressed smooth muscle alpha-actin, unlike DF cells. All cell types stained positive for certain collagens and proteoglycans, but DP and DS cells synthesized more glycosaminoglycans. Ultrastructurally, DP and DS cells formed intranuclear rodlets, which DF cells did not. In terms of cytokine production, DP cells produced the highest levels of TGF-beta 2, followed by DS and DF cells. These findings indicated that DP and DS cells were morphologically and functionally distinct from DF cells, with minor differences suggesting different functional or differentiation states within follicular mesenchymal cells.

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