Hyperandrogenism in Polycystic Ovary Syndrome

    January 2009
    Neoklis A. Georgopoulos, Eleni Kandaraki, Dimitrios Panidis
    TLDR In PCOS, high male hormones cause hair growth, acne, and hair loss, affecting periods.
    In women with polycystic ovary syndrome (PCOS), hyperandrogenism was clinically manifested by hirsutism, acne, and androgenic alopecia, contributing to chronic anovulation and menstrual dysfunction. Biochemically, it was characterized by elevated levels of serum total or unbound testosterone, androstenedione, and an increased free androgen index (FAI). Prospective studies indicated that hyperandrogenism affected about 1 in 10 women of reproductive age, although prevalence could increase up to 30% due to racial differences or patient selection criteria.
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