Hyperinnervation inhibits organ-level regeneration in mammalian skin
March 2026
in “
Cell
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Research cited in this study
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Muscles and nerves that cause goosebumps also help control hair growth.
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Stress can cause hair to turn gray by depleting stem cells.
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Lymphatic vessels are essential for hair follicle growth and skin regeneration.
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Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.
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PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
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Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
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Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
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Two fibroblast types shape skin structure and repair differently.
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Loss of Fz6 disrupts hair follicle and associated structures' orientation.
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African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.
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Different hair follicles in the skin are innervated by unique combinations of mechanosensory neurons, crucial for touch sensation.
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Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
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Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
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Mice healed without scars as fetuses but developed scars as adults, suggesting scarless healing might be replicated with further research.
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