Hypothalamic lipid metabolism and the control of food intake

    November 2016 in “ Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) ”
    Ahmed Hamed Arisha
    TLDR The VMH AMPK-SNS-BAT axis may help treat cachexia and obesity.
    The document discussed the role of hypothalamic lipid metabolism in regulating food intake and energy balance, highlighting the ventromedial nucleus of the hypothalamus (VMH) and AMP-activated protein kinase (AMPK) in controlling brown adipose tissue (BAT) thermogenesis. It was found that estrogens and androgens significantly influenced energy balance through central actions. Central estradiol (E2) treatment inhibited AMPK in the VMH, activating BAT thermogenesis independently of food intake, while dihydrotestosterone (DHT) treatment inhibited BAT thermogenesis and modulated lean mass. These findings suggested that the regulation of the VMH AMPK-SNS-BAT axis by E2 and DHT was crucial for energy balance, offering potential targets for treating cachexia and obesity.
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