I-PRF-Derived Exosomes Promote Hair Regeneration by Modulating Inflammatory, Oxidative, Angiogenic, and Regenerative Pathways in an Androgenetic Alopecia Mouse Model

    February 2026 in “ Trends in Sciences ”
    Adniana Nareswari, Paramasari Dirgahayu, Didik Gunawan Tamtomo, Harijono Kariosentono, Ratih Puspita Febrinasari, Muhammad Eko Irawanto
    TLDR i-PRF-derived exosomes can effectively promote hair growth and improve hair health in androgenetic alopecia.
    This study on androgenetic alopecia (AGA) used 30 male C57BL/6 mice to evaluate the effects of exosomes derived from injectable Platelet-Rich Fibrin (i-PRF). The mice were divided into six groups, including controls and treatment groups with i-PRF exosomes and minoxidil. The findings revealed that i-PRF-derived exosomes significantly decreased inflammatory, oxidative, and apoptotic markers while enhancing angiogenic and regenerative pathways. The combination of i-PRF exosomes with minoxidil showed the greatest improvements in dermal thickness and hair follicle density, indicating that i-PRF-derived exosomes could be a promising and safe therapy for AGA.
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