ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway

ICP5249, an autophagy activator, promotes hair growth by activating the AMPK-autophagy signaling pathway. The study demonstrated that ICP5249 increased proliferation and alkaline phosphatase expression in human dermal papilla cells, extended the length of human hair follicles, and enhanced hair growth in a telogenic mouse model. The compound also upregulated key proteins associated with autophagy and AMPK signaling. The use of an AMPK inhibitor, compound C, suppressed these effects, confirming the role of AMPK in ICP5249-induced hair growth. These findings suggest that ICP5249 could be a promising ingredient for enhancing hair growth.