Identification of Potential Hub Genes in Alopecia Areata

October 2024 in “ Experimental Dermatology ”

Runqiu Liu, Longdan Liu, Jiandan Xu, Xiaoting Wen, Yannan Jiang, Qi Qi, Jie Qin, Pingping Qin

TLDR CD8A and FOXD2-AS1 may be key for diagnosing and treating alopecia areata.

This study investigates the genetic basis of alopecia areata (AA) by analyzing gene expression data from AA patients and healthy controls. Researchers identified 173 differentially expressed genes (DEGs) related to cytokines, chemokines, and hair follicle development. A protein-protein interaction (PPI) network helped identify 24 hub genes, with five being upregulated. Additionally, 26 differentially expressed long non-coding RNAs (DElncRs) were found, including nine upregulated ones in the cytoplasm. An mRNA-miRNA-lncRNA regulatory network was constructed, highlighting the interaction between CD8A, mir-185-5p, and FOXD2-AS1 as potentially crucial in AA pathogenesis. CD8A and FOXD2-AS1 show promise as diagnostic markers and therapeutic targets for AA.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

16 / 16 results

research A novel predictive model for the recurrence of pediatric alopecia areata by bioinformatics analysis and a single-center prospective study

3 citations , June 2023 in “Frontiers in Medicine”

A new model uses specific blood markers to predict if children's hair loss will return.

research Alopecia Areata: An Updated Review for 2023

91 citations , May 2023 in “Journal of Cutaneous Medicine and Surgery”

Alopecia Areata affects 2% globally, with treatments like essential oils, garlic, and JAK inhibitors showing promise, but more research is needed.

research Biomarkers in Alopecia Areata: A Systematic Review and Meta-Analysis

4 citations , April 2023 in “Autoimmunity reviews”

High levels of IL6 and CRP, and low levels of vitamin D, might be indicators of alopecia areata.

research Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implications of Post-Translational Modifications

11 citations , June 2022 in “Frontiers in immunology”

New protein changes may be involved in the immune attack on hair follicles in alopecia areata.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Treatment of Pediatric Alopecia Areata: A Systematic Review

48 citations , April 2021 in “Journal of the American Academy of Dermatology”

Topical corticosteroids are the best initial treatment for children's alopecia areata.

research Frontiers in Alopecia Areata Pathobiology Research

55 citations , October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

research Identification of Blood MicroRNA Alterations in Patients With Severe Active Alopecia Areata

15 citations , April 2019 in “Journal of Cellular Biochemistry”

Certain blood miRNAs are linked to severe alopecia areata and could lead to new treatments.

research Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis

100 citations , July 2018 in “Journal of The American Academy of Dermatology”

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

research An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation

58 citations , July 2018 in “Journal of Allergy and Clinical Immunology”

Alopecia areata severity is linked to increased TH1 and TH2 activity.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations , September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

research Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis

128 citations , February 2016 in “British Journal of Dermatology”

Alopecia areata significantly lowers the quality of life, especially in emotional and mental health aspects.

research Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

Blocking IL-12/IL-23p40 helped reverse severe hair loss in patients.

research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.