TLDR Certain genetic variations in IGF2BP2 and IGFBP3 are linked to a higher risk of PCOS.
This study examined the association between IGF2BP2 and IGFBP3 gene polymorphisms and polycystic ovary syndrome (PCOS) in 300 southeast Iranian women. It found that the IGF2BP2 rs1470579 and IGFBP3 rs2854744 variants are significantly associated with an increased risk of PCOS, with odds ratios of 3.57 and 2.54, respectively. The research suggests that these genetic variations may influence PCOS development through insulin signaling pathways. Additionally, certain genotype combinations were linked to a reduced risk of PCOS. The study emphasizes the potential of genetic markers in understanding PCOS and highlights the need for further research to explore these genetic associations and their implications for managing PCOS.
6 citations
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December 2021 in “International Journal of Endocrinology” The genetic variant studied does not affect PCOS symptoms in Kashmiri women.
7 citations
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May 2019 in “Journal of the Formosan Medical Association” HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.
222 citations
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January 2014 in “International journal of reproductive medicine” Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.
1514 citations
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December 2011 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
215 citations
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January 2011 in “Reproductive Biology and Endocrinology” About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.
232 citations
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December 2005 in “Andrology” PCOS is caused by both genetics and environmental factors like diet and obesity.
4809 citations
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
6 citations
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April 2023 in “International Journal of Endocrinology” Mesenchymal stem cells could help treat diabetes and its complications by improving insulin function and reducing inflammation.
