IL-1 Receptor Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response After Exposure to UVB Radiation

In this study, IL-1 receptor-knockout (IL1r–/–) mice developed multiple epidermal cysts after chronic UVB exposure, unlike wild-type mice, and showed an altered immune response with reduced inflammation and increased resistance to UVB-induced cell death. The absence of IL-1R signaling was crucial for cyst formation, as IL1r–/– mice developed more cysts than other deficient mice. The study highlighted the unexpected role of IL-1R in epidermal homeostasis and suggested further investigation into IL-1 ligands' role in epidermal repair and immune response post-UVB exposure, providing insights into potential therapeutic targets for UV-induced skin damage.