Interleukin-10-Deficient Mice Are Less Susceptible to the Induction of Alopecia Areata

The study explored the role of interleukin-10 (IL-10) in alopecia areata (AA) using 20 IL-10-deficient mice and 20 normal mice. It was discovered that IL-10-deficient mice were less susceptible to AA induction, experiencing significantly less hair loss after skin grafting compared to normal mice. This suggested that IL-10 might have a proinflammatory role in AA pathogenesis, contrary to its usual immunosuppressive function in other autoimmune conditions. Consequently, IL-10 was deemed unlikely to be a viable therapeutic option for AA, as it appeared to promote the disease rather than suppress it.