IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles

August 2023 in “ Journal of Investigative Dermatology ”

Takahiro Suzuki, FERNANDA DINELLI SCALA, Dana‐Lee Demetrius, Jennifer Gherardini, Jose Rodriguez-Feliz, Gorana Kuka-Epstein, Jérémy Chéret, Ralf Paus

IL-15 anagen phase hair matrix cytokines hair follicle cycling apoptosis cell proliferation

TLDR IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.

The study investigates the role of IL-15 in human scalp hair follicles, revealing that IL-15 prolongs the anagen phase, stimulates cell proliferation, and suppresses apoptosis in the hair matrix. These findings suggest that IL-15 could be a significant factor in regulating hair growth by influencing the hair cycle, particularly the transition from growth to regression phases. Understanding the impact of cytokines like IL-15 on hair follicle cycling could provide insights into potential treatments for hair loss conditions.

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