Serum Interleukin-37 and Its Gene Polymorphism (rs3811047) in Egyptian Patients with Alopecia Areata

This study investigated the role of serum interleukin-37 (IL-37) and its gene polymorphism (rs3811047) in 40 Egyptian patients with alopecia areata (AA) compared to 45 healthy controls. Results showed that serum IL-37 levels were significantly higher in AA patients and positively correlated with the Severity of Alopecia Tool (SALT) score, indicating a link between IL-37 levels and disease severity. However, no significant association was found between the IL-37 gene polymorphism (rs3811047) and the risk of developing AA. The findings suggest that while serum IL-37 is involved in the pathophysiology and severity of AA, the gene polymorphism does not contribute to the disease risk.