Successful Treatment of Generalized Discoid Lupus Erythematosus With Imiquimod Cream 5%: A Case Report and Review of the Literature

January 2014 in “ PubMed ”

Michael Park, Barbara Boone, Steven A. Devos

discoid lupus erythematosus DLE imiquimod topical treatment erythematous scaly patches hair loss skin condition imiquimod cream

TLDR Imiquimod cream 5% effectively treated generalized discoid lupus erythematosus.

Discoid lupus erythematosus (DLE) is a chronic skin condition that can lead to scarring, hair loss, and pigmentary changes if not treated early. A case study of a 63-year-old man with generalized DLE, presenting with erythematous scaly patches on the face and other body parts, demonstrated successful treatment using imiquimod cream 5%. The cream was applied three times a week, every other week, resulting in almost complete recovery after 24 applications over two months. This case suggested that topical imiquimod could be an alternative treatment for generalized DLE.

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research Unusual Clinical Manifestations of Chronic Discoid Lupus Erythematosus

1 citations , June 2014 in “Serbian Journal of Dermatology and Venereology”

A woman with discoid lupus improved with treatment after being misdiagnosed with a different hair loss condition.

research Discoid Lupus Erythematosus Presenting with Cysts, Comedones, and Cicatricial Alopecia on the Scalp

14 citations , May 2009 in “Journal of the American Academy of Dermatology”

The patient's scalp lesions stabilized with a combination of treatments after initial therapies failed.