Modification of the Immune System with Hydrogen Sulfide and Cyclosporine A

The study investigated the effects of hydrogen sulfide (H2S) on the immune system in laboratory rats, focusing on age-related differences and the impact of immunosuppression. It was found that H2S without immunosuppression increased the ratio of T-helper CD4+/T-killer CD8+, interstitial interleukin-6, and calcium levels in the blood. Under immunosuppression, there was an increase in natural killer cells CD16+, activation of complement system components (C3, C4), and B-lymphocytes CD19+ across all age groups, with older rats showing a weakened index and increased phagocytosis. These findings suggest that age-related changes in the immune system significantly contribute to the development of pathologies in other systems.