Immunohistochemical Localization of Fatty Acid Transporters and MCT1 in the Sebaceous Glands of Mouse Skin

    January 2016 in “ Institutional Repositories DataBase (IRDB) ”
    Miao Zheng, Shinhye Lee, Satoshi Tsuzuki, Kazuo Inoue, Daisaku Masuda, Shizuya Yamashita, Toshihiko Iwanaga
    TLDR Sebaceous glands help study fatty acid transporters and binding proteins.
    The study investigated the expression and localization of fatty acid transporters and binding proteins, specifically CD36, MCT1, FATP4, and E-FABP, in the sebaceous glands of mice, including the meibomian and preputial glands. It was found that CD36 and MCT1 were largely co-localized along the plasma membrane of secretory cells in sebaceous glands, but were separately expressed in the glandular portions of meibomian and preputial glands. FATP4 and E-FABP showed diffuse immunoreactivity in the cytoplasm of secretory cells. The genetic deletion of CD36 did not affect the localization of the other molecules. The study concluded that sebaceous glands were useful for analyzing the functions and relationships of fatty acid transporters and binding proteins.
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