In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

    May 2022 in “ Frontiers in physiology ”
    Ziqiang Feng, He Gong, Jinhong Fu, Xiaohui Xu, Yupu Song, Xiaomin Yan, Ichraf Mabrouk, Yifang Zhou, Yudong Wang, Xianou Fu, Yuanyuan Sui, Tuoya Liu, Chuanghang Li, Zebei Liu, Tian Xu, Li‐Zhong Sun, Keying Guo, Yongfeng Sun, Jingtao Hu
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    TLDR Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.
    The study investigated the effects of CHIR-99021, an activator of the Wnt/β-catenin signaling pathway, on feather follicle development in goose embryos (Anser cygnoides). Goose embryos were injected with CHIR-99021 at the onset of feather follicle development (E9), resulting in enhanced feather growth and follicle development. This was attributed to the activation of the Wnt signaling pathway through the inhibition of GSK-3β. Transcriptomic analysis revealed changes in gene expression related to translation, metabolism, energy transport, and stress in the dorsal tissue of embryos treated with CHIR-99021. These changes are believed to support the accelerated development of feather follicles. The study suggests that in ovo injection of CHIR-99021 could be a viable method to improve feather production in geese and provides insight into the molecular mechanisms involved in feather follicle development.
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